LIF and neoplasm: In general, cellular components of the TME, such as TAMs, MDSCs, DCs, and CAFs, secrete different cytokines, among which members of the IL-6 family, including leukemia inducible factor (LIF), IL-10, TNF-α, and TGF-β [85], that affect both tumor cells and other stromal components of the TME through different mechanisms, including epigenetic regulation.