MEN1 and neoplasm: Other hypermethylated tumor suppressors in PanNETs include PHLDA3, which downregulates the PI3K/AKT oncogenic signaling pathway [35], SSTR2, a G-protein coupled receptor that inhibits the release of hormones [36], APC, an antagonist of the Wnt/β-catenin pathway, and MEN1 and MGMT, encoding for DNA repair proteins involved in cellular defense (Figure 2B) [37,38].