Additionally, in pancreatic NETs, the upregulation of miR-21 has been observed, similarly to what has been observed for miR-196a, which regulates Akt signaling, and miR-670-3p, which regulates claudins CLDN1 and CLDN2, whose dysregulated expression is associated with tumor initiation, progression, and metastasis (Figure 2B) [69,70,71]. The gene discussed is AKT1; the disease is neoplasm.