Figure 1 shows results from Ki67 staining in normal colonic mucosa, normal-appearing colonic mucosa from FAP patients, and adenomas. In normal, FAP, adenomatous crypts, Ki67 staining (Figure 1) shows cycling cells are localized to the lower crypt but absent at the bottom-most region of the crypt located next to the muscularis mucosa. This evidence concerns the gene MKI67 and Familial adenomatous polyposis.