These methodological inconsistencies—including the use of TPS, CPS or IC scores, heterogeneous positivity cutoffs, and non-harmonized antibody clones and assay platforms—substantially complicate cross-trial comparisons and may, at least in part, account for the apparently contradictory observations regarding the predictive value of PD-L1 in HCC [121]. Here, CD274 is linked to hepatocellular carcinoma.