In immunotherapy-resistant liver cancer tissues, transforming acidic coiled-coil containing protein 3 (TACC3) is highly expressed and capable of reprogramming polyunsaturated fatty acid metabolism via acyl-CoA synthetase long-chain family member 4 (ACSL4), through pathways involving La-related protein 1 (LARP1) and poly(A)-binding protein cytoplasmic 1 (PABPC1). This evidence concerns the gene ACSL4 and liver cancer.