For example, in non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC) syngeneic mouse models, Song et al. observed improved tumor control with ADA1/CAR T cells, along with evidence of decreased T cell exhaustion and preservation of long-term function, but without significant elevations in serum pro-inflammatory cytokines or indicators of systemic toxicity [19]. Here, ADA is linked to non-small cell lung carcinoma.