To elucidate the sustained molecular effects of HOC on NEPC during tumor recurrence, protein expression levels of EPHA3, BRN2, EZH2, ASCL1, DLL3, SYP, and CHGA were examined in NCI-H660-Luc recurrence tumors collected at the study end, which were compared with those observed in primary tumors. This evidence concerns the gene POU3F2 and neoplasm.