Regarding O6-methylguanine DNA methyltransferase (MGMT) promoter methylation, He et al. applied a Transformer-based weakly supervised model to TCGA-glioblastoma and an independent Beijing cohort, achieving AUCs of 0.86 and 0.83, with accuracies of 0.79 and 0.76, respectively–evidence of external reproducibility [69]. Here, MGMT is linked to glioblastoma.