Thanks to a recent advancement in machine learning (ML) technology and multidisciplinary efforts, AI has achieved notable milestones in molecular prediction including IDH mutation, 1p/19q-codel, and MGMT methylation (prognostic/predictive epigenetic biomarker in glioblastoma), showing promise with AI-based architectures [3,28,29,30]. The gene discussed is MGMT; the disease is glioblastoma.