As expected, LDL cholesterol level was significantly lower in the carriers of variants in APOB compared to the non‐carriers (51 mg/dL vs. 148 mg/dL, respectively, p‐value = 6.08 × 10−09), consistent with the known biochemical phenotype of heterozygous hypobetalipoproteinemia along with low total cholesterol levels. The gene discussed is APOB; the disease is hypobetalipoproteinemia.