Consistent with clinical findings, experiments in a DHT-induced PCOS rat model demonstrated that acupuncture significantly improved insulin resistance, estrous cyclicity, reduced body fat, increased serum SHBG levels and changed ovarian FGF19 expression compared to PCOS, indicating acupuncture effectively mitigates endocrine disorder and insulin resistance in PCOS pathophysiology. The gene discussed is SHBG; the disease is Insulin resistance.