This study aims to elucidate the role of AGPAT4 in thyroid cancer by investigating its expression, involvement in metabolic pathways, and potential as a prognostic biomarker.<h4>Methods</h4>We analyzed data from 512 thyroid cancer patients and 279 controls, performed differential expression analysis of AGPAT4 in thyroid cancer, analyzed the gene expression correlation of AGPAT4 in thyroid cancer, and the protein-protein interaction (PPI) network and functional enrichment analysis of AGPAT4 and its differentially expressed genes (DEGs) were constructed. Here, AGPAT4 is linked to thyroid cancer.