IL10 and neoplasm: Findings from this patient suggested that interleukin (IL)-10 secretion by M2 macrophages may be an initiating factor in the mechanisms that regulate tumour growth; however, this interpretation is hypothesis-generating and based on a small number of cases.<h4>Conclusion</h4>Assessing the prognosis of LCH-OMF requires a comprehensive consideration of the disease type, age, CNS-risk regions, risk organs, acute systemic inflammatory response, and skin involvement.