Researches show that nuciferine and yellow tea polysaccharides promote CYP7A1/CYP27A1-mediated bile acid synthesis while inhibiting ileal FXR signaling, thereby enhancing fecal bile acid excretion and improving hepatic lipid metabolism in HFD-induced NAFLD [110, 111]. Here, NR1H4 is linked to metabolic dysfunction-associated steatotic liver disease.