Studies have shown that pyroptosis of intestinal macrophages can occur in HFD-induced NAFLD, and Poria cocos polysaccharides effectively reduced pyroptosis-driven intestinal vascular barrier disruption by regulating PARP-1, increased the expression of Occludin and ZO-1, reduced endotoxin translocation, and alleviated the progression of NAFLD [98]. This evidence concerns the gene PARP1 and metabolic dysfunction-associated steatotic liver disease.