SDC1 and periodontitis: This study aimed to investigate the role of P. gingivalis OMVs in vascular endothelial glycocalyx injury.<h4>Methods</h4>In this clinical study, serum levels of syndecan-1 (SDC1) and heparan sulfate (HS), biomarkers of endothelial glycocalyx injury, were measured and compared between patients with stage III-IV periodontitis and those with stage I-II or no periodontitis.