Therefore, our first key recommendation based on our findings, is for health facilities to urgently consider dengue virus testing as a differential diagnosis for malaria during rainy season, and to encourage laboratory facilities to conduct PCR-tests (if available) or utilize antigen-based dengue fever rapid diagnostic tests (RDT) for patients during the acute phase of the infection (up to seven days after start of fever), followed by IgM RDTs for patients that delayed presentation to the clinic for more than seven days after onset of symptoms. The gene discussed is CD40LG; the disease is malaria.