In addition, elevations of serum NOTCH3-ECD were not observed in individuals with other WHO group 1 subgroups, including heritable PAH (Fig. 3b), other vasculitides including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (Fig. 3c), or malignancies known to express NOTCH3 (Fig. 3d). This evidence concerns the gene NOTCH3 and cerebral arteriopathy with subcortical infarcts and leukoencephalopathy.