Multivariable logistic regression analysis identified female (OR = 3.44, 95%CI: 1.77-6.80, P < 0.01), decreased grip strength (per 1 kg decrease) (OR = 1.05, 95%CI: 1.00-1.09, P < 0.05), and decreased albumin levels (per 1 g/L decrease) (OR = 1.11, 95%CI: 1.01-1.22, P = 0.03) as independent risk factors for CKD-associated osteoporosis. This evidence concerns the gene ALB and osteoporosis.