Recently, genetic variants in the CACNA1D gene, which encodes the α<sub>1</sub>-subunit of voltage-gated Ca<sub>v</sub>1.3 L-type Ca<sup>2+</sup>-channels, were linked to neurodevelopmental disorders, but their pathophysiological role on neuronal activity and development in a human background remains unknown. The gene discussed is CACNA1D; the disease is neurodevelopmental disorder.