Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most prevalent form of dementia, impacting memory, behavior, and cognitive abilities [1–3] by distinct neurologically-defined clinical stages as well as the presence of extracellular amyloid beta (Aβ) plaques/deposits and intracellular tau tangles in the brain [4–7]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.