Based on the potential correlation between ZC3H15 and tumor growth and lymph node metastasis, as well as its association with the cell cycle identified by gene set enrichment analysis (GSEA), we hypothesized that ZC3H15 may play an important role in cell proliferation, migration and invasion (Supplementary Fig. 2A). The gene discussed is ZC3H15; the disease is metastatic malignant neoplasm in the lymph nodes.