As shown in Fig. 1F, among all known ligand-receptor pairs, control samples were dominated by the EGF-EGFR interaction, while in DMD, we observed a substantial contribution of other ligand and receptors; EGF ligand binding the EGFR-ERBB2 receptor, EFEMP1 ligand binding the EGFR-ERBB2 receptor but also the ERRB-ERBB4 receptor. The gene discussed is EFEMP1; the disease is Duchenne muscular dystrophy.