S100A8 and neoplasm: It’s important to note that as an inflammatory mediator, S100A8/A9 also interacts with various tumor signaling pathways such as toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE), and can form a positive feedback loop with MAPK, NF-κB and other signaling pathways, thereby promoting the proliferation, migration and invasion of tumor cells [19].