Using RNAseq data (GEO# GSE138312) from a previously described cohort of iPSC-Heps from MASH cases and healthy controls [15], we found that iPSC-Heps from MASH cases had lower levels of PNPLA3 and TM6SF2 (Fig. 1H), which contain loss-of-function alleles that promote MASH development [16, 17]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatohepatitis.