In C57BL/6 J male mice fed the metabolic dysfunction associated steatohepatitis (MASH)-inducing GAN diet (40% kcal fat, 20% kcal fructose, 2% cholesterol) (Supplementary Fig. S1C),Tmem55b ASO treated animals had a higher level of fibrosis after 21 and 29-weeks on diet (Fig. 1C). Here, PIP4P1 is linked to metabolic dysfunction-associated steatohepatitis.