Previous studies have shown that the ratio of the expression of MAT1A, an oncogene, to that of MAT2A is positively correlated with HCC survival, the conversion of MAT1A to MAT2A reduces the biosynthesis of S-adenosylmethionine (SAMe), providing favorable conditions for cancer cell growth [52]. The gene discussed is MAT2A; the disease is hepatocellular carcinoma.