In a study of CCA, Wu et al. [123] reported that mIDH1 inhibits CD8+ T-cell recruitment and IFNγ-TET2 signaling and promotes immune escape and tumor maintenance in CCA, demonstrating the importance of immune function and the IFNγ-TET2 axis in mIDH1 inhibition. This evidence concerns the gene TET2 and cholangiocarcinoma.