HIF1A and cancer: The activation of HIF-1 promotes ubiquitination within cancer cells, while overexpression of the biomarker annexin A1 (ANXA1) can recruit the deubiquitinating enzyme USP5 to stabilize key enzymes in glutamine metabolism, synergistically enhancing glutamine uptake and glutamate production, and alleviating oxidative stress at the tumor site to inhibit tumor growth [36].