MAT1A and neoplasm: Studies have shown that a direct interaction between MATα1 and 14-3-3ζ occurs and is enhanced by AKT2 phosphorylation of MATα1, and the overexpression of 14-3-3ζ decreases nuclear MATα1 levels and promotes tumor progression; thus, mutual negative regulation of MATα1 and 14-3-3ζ is a key mechanism in liver tumorigenesis [54].