BCL2 and idiopathic pulmonary fibrosis: This study reveals that anti-HSP70 autoantibodies in patients with IPF enhance apoptosis resistance via an epigenetic mechanism—specifically, treatment with these autoantibodies markedly increases acetylation of lysine 16 on histone H4 (H4K16Ac) at the Bcl-2 gene promoter (p < 0.05), thereby upregulating Bcl-2 expression and suppressing apoptosis.