In gastric cancer patients, STAT3 can bind to the consensus DNA response elements within the promoters of NR-related genes (GPX4, SLC7A11, and FTH1) and promote the expression of these ferroptosis-negative regulators, thereby establishing a negative STAT3–ferroptosis regulatory axis [231] (Fig. 6H, Bottom left). This evidence concerns the gene FTH1 and gastric cancer.