In cervical cancer, human papillomavirus (HPV) oncogenes E6 and E7 upregulate TUBORF through p300-mediated acetylation of histone H3 at lysine 27 (H3K27ac) on one hand; on the other hand, recruitment of Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1 (ESCO1) enables its binding to TUBORF, leading to acetylation of TUBORF at K10 and K16. The gene discussed is ESCO1; the disease is cervical cancer.