High Mobility Group AT-hook 2 (HMGA2) is a critical transcription factor that, in pancreatic cancer patients, binds to and promotes modifications of the cis-regulatory elements in the GPX4 gene promoter region, enhancing enhancer activity by increasing H3K4 methylation and H3K27 acetylation [225] (Fig. 6E, Middle). Here, HMGA2 is linked to pancreatic neoplasm.