To investigate the heterogeneity of the neoplastic TME in AITL, the abundances of naïve CD4 T cells, naïve B cells, and FDCs were projected to the frozen sections of AITL with H&E staining, which represented GCs, B follicles, and T-cell zones, respectively. This evidence concerns the gene CD4 and angioimmunoblastic T-cell lymphoma.