ALDH3A1 and acute respiratory distress syndrome: In the final part of this study, to uncover whether IMP’s therapeutic effects on ALI in vivo were AHR/ALDH3A1-dependent, we pharmacologically inhibited endogenous AHR (using the antagonist CH) and ALDH3A1 (using the inhibitor ALDH-IN) in ALI mice (Fig. 8A).