PCNA and hepatocellular carcinoma: The sgUCE mice also showed high levels of an HCC marker HSP70 and faster proliferation of the hepatocytes than the mice with only c-MET/sgAxin1, indicated by the proliferation marker proliferating cell nuclear antigen (PCNA) and the mammalian target of rapamycin C1 (mTORC1) signals (phospho-S6 S235/236 and phospho-4EBP1 T37/46) (Fig. 4G).