Because of the drastic difference between the c-MET/β-catenin and c-MET/sgAxin1 models in their regulation in UCE expression, in the following studies, we used the c-MET/β-catenin model to characterize the effect of UCE down-regulation and used the c-MET/sgAXIN1 model to study the effect of UCE silencing on nitrogen metabolism and HCC development. Here, MET is linked to hepatocellular carcinoma.