TYR and neoplasm: Such variations reflect the influence of environmental factors (temperature, altitude, rainfall, soil composition), solvent used during extraction processes, and the plant organ on the concentration of bioactive metabolites [38,39].The enzymatic modulation exhibited by the hydroalcoholic extract of B. pilosa, characterized by moderate collagenase inhibition (53.9%), high hyaluronidase inhibition (64.5%), and low tyrosinase inhibition (11.1%), highlights its potential to protect the extracellular matrix and preserve hyaluronic acid, thereby contributing to the prevention of skin aging.