Digitoxin, a cardiac glycoside commonly used to treat heart failure and arrhythmias, demonstrated strong affinity for the highly conserved ATP-binding pocket of mTOR, including residues Ile2163, Ser2165, Lys2187, Glu2190, Tyr2225, Trp2239, Val2240, Thr2245, Ser2342, Asn2343, Met2345, Ile2356, and Asp2357 [36]. Here, MTOR is linked to heart failure.