77 drugs with interaction with STAT1 were found, such as Budesonide, N-Acetyl-L-cysteine, Prenylamine, Chlorophyllin, and Suloctidil.Although this study systematically identified hub genes associated with cellular senescence in allergic rhinitis (AR) using integrated bioinformatics approaches, several limitations should be acknowledged. Here, STAT1 is linked to allergic rhinitis.