Previous studies further support their clinical relevance: RGS5 has been implicated in liver cancer recurrence, venous infiltration, and poor survival [31]; SULT1C2 has been strongly associated with LC [32]; CXCL14 is recognized as a tumor suppressor and prognostic factor [33]; and ACSM3 has also been reported in LC progression [34]. This evidence concerns the gene ACSM3 and laryngotracheoesophageal cleft.