Four survival-associated genes (RGS5, SULT1C2, ACSM3, CXCL14) and ten hub genes (CCNB2, CDC25C, NEK2, CDCA5, CDK1, PPP1CA, PPP1CC, PPP1CB, CAMK2B, CDC20) consistently emerged as key drivers of LC progression. Here, RGS5 is linked to laryngotracheoesophageal cleft.