Four survival-associated genes (RGS5, SULT1C2, ACSM3, CXCL14) and ten hub genes (CCNB2, CDC25C, NEK2, CDCA5, CDK1, PPP1CA, PPP1CC, PPP1CB, CAMK2B, CDC20) consistently emerged as key drivers of LC progression. The gene discussed is CDC20; the disease is laryngotracheoesophageal cleft.