Four survival-associated genes (RGS5, SULT1C2, ACSM3, CXCL14) and ten hub genes (CCNB2, CDC25C, NEK2, CDCA5, CDK1, PPP1CA, PPP1CC, PPP1CB, CAMK2B, CDC20) consistently emerged as key drivers of LC progression. This evidence concerns the gene CDCA5 and laryngotracheoesophageal cleft.