Four survival-associated genes (RGS5, SULT1C2, ACSM3, CXCL14) and ten hub genes (CCNB2, CDC25C, NEK2, CDCA5, CDK1, PPP1CA, PPP1CC, PPP1CB, CAMK2B, CDC20) consistently emerged as key drivers of LC progression. Here, CCNB2 is linked to laryngotracheoesophageal cleft.