This revealed ten hub genes (CCNB2, CDC25C, NEK2, CDCA5, CDK1, PPP1CA, PPP1CC, PPP1CB, CAMK2B, and CDC20), many of which are established drivers of LC progression, cell-cycle dysregulation, and poor prognosis. The gene discussed is CDC20; the disease is laryngotracheoesophageal cleft.