Notably, 6 significant genes (FCN2, FREM2, GLS2, ACSM3, FAM134B, and HIST1H3H) were commonly dysregulated among LC, CHRS, and HTCV; NOX4, CDH13 and FLJ37035 were commonly dysregulated among LC, T2D, and HTCV. Here, ACSM3 is linked to laryngotracheoesophageal cleft.