It has demonstrated comparable effectiveness to insulin, with added benefits, such as lower rates of preeclampsia and NICU admissions and greater ease of administration.13,14 In gestational diabetes, metformin has been effective not only in controlling maternal hyperglycemia but also in reducing the incidence of neonatal hypoglycemia compared with insulin, suggesting superior efficacy in preventing this complication.13,14. The gene discussed is INS; the disease is preeclampsia.