Klothodownregulation resulting from epigenetic silencing was linked with prematurekidney function deterioration and increased oxidative stress, vascularcalcification, and fibrosis, ultimately leading to worsening CKD outcomes.In addition, Ko et al.64 investigated genome-wide methylation status and detected extensiveglobal DNA hypomethylation in CKD patients, especially ininflammation-related genes such as NF-κB pathway genes. The gene discussed is NFKB1; the disease is chronic kidney disease.