TP53 and cancer: Among the 129 identified drivers (Supplementary Table S1), the “Filter Dubious Genes” option eliminated six genes (see Methods) (Supplementary Table S4), resulting in 123 potential driver genes, of which nearly 50% of the predicted genes are widely recognized “Known Drivers” (see Methods) with proven oncogenic or tumor suppressor roles (Fig. 4B, Supplementary Fig. S2), including well-established cancer genes such as TP53, PIK3CA, and KRAS.