Due to the important role of EGFR-STAT3 signaling in tumorigenesis, including HNSCC, we investigated whether SOX11 is upregulated by EGF in four HNSCC cell lines, including two highly invasive UM1 and UMSCC5 and two low-invasive UM2 and UMSCC6. Here, SOX11 is linked to head and neck squamous cell carcinoma.