IGFBP6 and intrahepatic cholangiocarcinoma: Public cancer atlases consolidate that IGFBP-6 is variably expressed across tumors with context-specific survival associations, but liver-specific prognostic signals remain unresolved at the population level, underscoring the need for liver hepatocellular carcinoma/intrahepatic cholangiocarcinoma (LIHC/iCCA)-focused analyses rather than pan-cancer extrapolation [108].