In desmoid tumors (aggressive fibromatosis), stabilized β-catenin represses IGFBP-6 expression, and promoter/EMSA studies identified functional β-catenin/T-cell factor (TCF)-responsive elements in the human IGFBP-6 promoter, supporting direct transcriptional repression by the β-catenin/TCF complex [33]. This evidence concerns the gene HNF4A and desmoid tumor.