In iCCA and stroma-rich HCC, CAF-resolved spatial profiling of IGFBP-6 (RNA/protein) should be paired with CAF-state scoring and ligand–receptor inference to identify stromal neighborhoods where IGFBP-driven paracrine control of IGF signaling is most active and therapeutically exploitable [113,114]. This evidence concerns the gene IGFBP6 and hepatocellular carcinoma.