IGFBP6 and portal hypertension: Liver-sinusoidal endothelial cell remodeling and collagen IV deposition have been causally linked to portal hypertension, providing a microenvironmental context where stromal IGFBP-family dynamics—including IGFBP-6—could change with vascular remodeling, though direct IGFBP-6 data in this setting remain to be generated [95].