Protein variants in the renin-angiotensin aldosterone system (RAAS), such as angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II receptor type I (ATR1), are directly implicated in hypertension as they promote vasoconstriction and sodium retention, which raises blood volume and blood pressure [203]. The gene discussed is ACE; the disease is hypertensive disorder.