EFEMP2 and cutis laxa: The genes associated with cutis laxa encode proteins that are either structural components of elastic fibers (e.g., elastin from ELN, fibulins from FBLN5 and FBLN4/EFEMP2) or are required for their assembly, secretion, and crosslinking (e.g., elastic fiber maturation from LTBP4 and ER-mediated ECM protein processing from ATP6V0A2) [27,124,125].