LMNA and Hutchinson-Gilford progeria syndrome: Classic Hutchinson-Gilford Progeria syndrome (HGPS) is caused by the mutation c.1824C>T (p.Gly608=) of LMNA, which activates a cryptic splice site in exon 11, producing progerin (lamin A Δ50), a prelamin A variant missing 50 amino acids near the C-terminus and therefore retaining farnesylation.