ZBTB16 and alcoholic hepatitis: -Reduced in circulation (most profound in alcoholic hepatitis) but retained in the liver; chronic activation signatures-Functional changes: Impaired antibacterial effector function to E. coli stimulation (reduced IL-17A and cytotoxic readouts) with transcription factor defects (PLZF, RORC, EOMES, TBET); functional impairment partially restored with alcohol abstinence in early stage of disease.