Notably, many of the conserved signaling modules implicated here, including Ras/Rac GTPase regulation, ArfGEF-dependent trafficking, and TORC2-mediated polarity control, also play central roles in directional migration and invasion of cancer cells, underscoring the value of Dictyostelium as a model for fundamental eukaryotic motility pathways. This evidence concerns the gene CRTC2 and cancer.