BCL2 and central nervous system cancer: Although direct glioma-specific evidence linking PLCγ1/PKC-mediated phosphorylation to disruption of the Bcl-2:beclin-1 complex is limited, existing studies demonstrate that PLCγ1-driven Ca2+ flux modulates autophagy-apoptosis balance by influencing beclin-1 availability at the ER membrane [36,39,40,41,42,43].