While several recent reviews comprehensively describe autophagy-apoptosis interplay in GBM, few explicitly integrate the role of TrkB receptor signalling networks (PI3K/Akt/mTOR, Ras/Raf/MEK/ERK, and PLCγ1/PKC) as central modulators of this crosstalk. This evidence concerns the gene PLCG1 and glioblastoma.