The malignant character of high-grade gliomas and their PCD-resistance is closely linked to the severe activation of the TrkB receptor and its downstream PI3K/Akt/mTOR, Ras/Raf/MEK/ERK, and PLCγ1/PKC pathways overexpression, which normally regulate neuronal and glial survival, proliferation, and differentiation but become dysregulated to sustain uncontrolled growth (Figure 1). Here, MAP2K7 is linked to central nervous system cancer.