BECN1 and glioblastoma: For example, newly described BH3-mimetic molecules, BAU-243 and ABT737, bind Bcl-2 with high affinity and disrupt the Bcl-2:beclin-1 complex in GBM cells, leading predominantly to autophagic cell death rather than apoptosis and importantly, they reduced tumour growth in an in vitro and in vivo glioblastoma model [91,112].