AKT1 and neoplasm: In NSCLC, microRNA-128, a tumor suppressor, is involved in cancer differentiation and LN metastasis, inhibition of lymphangiogenesis through directly targeting VEGF-C, and blockage of extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (AKT), and p38 signaling [97].