Moreover, VEGF-C/VEGFR-3 signaling inhibition by VEGFR-3 monoclonal antibody, a soluble VEGF-C/-D trap, or deletion of Vegfr3 gene in adult mice leads to notable regression and functional impairment of dural lymphatic vessels, but without effect on CNS autoimmunity development [156]. This evidence concerns the gene FLT4 and Autoimmunity.