In murine models, melanoma-derived small EVs are enriched in the nerve growth factor receptor (NGFR), which enhances lymphangiogenesis and tumor cell adhesion by inducing ERK kinase, nuclear factor-κB (NF-κB) activation, and intracellular adhesion molecule (ICAM)-1 expression in LECs, and thus reinforcing LN pre-metastatic niche formation and metastasis [92]. Here, NFKB1 is linked to neoplasm.