A study has identified that lncRNA is highly upregulated in metastatic triple-negative breast cancer, in which hypomethylation promotes tumor cell proliferation, LN metastasis, and lymphangiogenesis by activating forkhead box k1 (FOXK1)-mediated Akt/mTOR and VEGF-C signaling [94]. This evidence concerns the gene AKT1 and neoplasm.