THBS1 and early-onset autosomal dominant Alzheimer disease: Long-term exercise protects against Alzheimer’s disease by enhancing the plasticity and drainage of meningeal lymphatic vessels through downregulation of the eleven-nineteen lysine-rich leukemia-associated factor-2 (EAF-2)-p53-thrombospondin-1 (TSP-1) pathway associated with reactive astrocytes [43].