Increased VEGF-C expression and LVD in TME of human melanoma show significant positive correlation with tumor-infiltrating CD8+ T cells and expression of immunosuppressive molecules, e.g., inducible nitric oxide synthase (iNOS), indoleamine 2,3-dioxygenase (IDO), and arginase-1 (ARG-1) [58]. The gene discussed is NOS2; the disease is melanoma.