Our study demonstrated that increased Cav2.2 protein expression in the spinal dorsal horn of lupus mice with chronic pain is associated with elevated TLR7 expression, and that activation of TLR7 with a TLR7 agonist in the normal spinal cord upregulates Cav2.2 (Figure 5). Here, CACNA1B is linked to systemic lupus erythematosus.