Comparison between vehicle-treated (n = 6) and ODN 2088-treated (n = 7) MRL/lpr mice confirmed that ODN 2088 significantly increased withdrawal latencies at 60 min and 90 min post-injection (p < 0.01), indicating that TLR7 blockade alleviates thermal hyperalgesia in lupus mice. This evidence concerns the gene TLR7 and systemic lupus erythematosus.