Zhang et al. explored HF’s suppression of MDM2 expression using cycloheximide and MG132; results indicated HF did not alter MDM2 degradation but dose- and time-dependently inhibited MDM2 mRNA synthesis, relieving p53 repression and activating apoptosis in HCT116 colon cancer cells. The gene discussed is TP53; the disease is malignant colon neoplasm.