The work by Goossens et al. (2021) provided a foundational overview of C–O–C-type biflavonoids, focusing on HF’s general anticancer properties and early mechanisms, notably its role as a sentrin-specific protease 1 (SENP1) inhibitor and modulator of the extracellular signal-regulated kinase (ERK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway [22]. The gene discussed is SENP1; the disease is hydrops fetalis.