Similarly, Olivito et al. demonstrated that KD could rescue social and cognitive deficits, as well as repetitive behaviors, by remodeling the gut–brain axis—elevating the relative abundance of beneficial microbiota such as Akkermansia and Blautia, suppressing plasma and brain expression of TNFα, IL-1β, and IL-6, reducing lipid peroxidation, and improving SOD activity in BTBR mouse brain regions [182]. This evidence concerns the gene SOD1 and Cognitive impairment.