In a study by Wang et al., treatment of a rat model of ASD induced by prenatal lipopolysaccharide (LPS) injection using L. reuteri or LGG for three weeks post-birth rescued social deficits and anxiety-like behaviors by elevating butyric acid levels, reducing propionic acid levels, improving colonic barrier integrity via up-regulation of tight junction proteins (ZO-1, Occludin, and Claudin4), mitigating HPA axis overactivation, and suppressing OS in the colon [128]. The gene discussed is TJP1; the disease is Anxiety.