Both IGF-I and IGF-II factors stimulate the growth of NB cell lines through the activation of signal cascades, including the phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT) and mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK) pathways [112]. This evidence concerns the gene AKT1 and neuroblastoma.