BCL-2 activity is directly controlled by AKT/mammalian target of rapamycin (mTOR) signalling, and a combination of crizotinib with mTOR inhibitor Torin2 prolonged survival of mice with ALKF1174L/MYCN NB tumours, which overexpress BCL-2 and are resistant to crizotinib [280]. Here, MTOR is linked to neuroblastoma.