This assertion is supported by the fact that biallelic mutations in the EIF2AK4 gene cause pulmonary vascular dysfunction, which is classified as either pulmonary veno-occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH), depending on the predominant histopathological features observed. This evidence concerns the gene EIF2AK4 and pulmonary venoocclusive disease.