In this study, we identified the following key findings: 1) IS appeared to be particularly associated with inflammatory responses mediated by IL‐6 both in CKD patients and cultured endothelial cells, 2) Ave suppressed IS‐induced inflammatory responses, and 3) Ave may modulate AhR signaling, which could contribute to the suppression of the inflammatory response. The gene discussed is AHR; the disease is chronic kidney disease.