KRT14 and epidermolysis bullosa simplex: The main disorder associated with KRT14 (and KRT5), EBS, is typically caused by dominantly acting missense alleles (Coulombe et al., 2009) but also arises in individuals whose genome is homozygous for the equivalent of null alleles (Chan et al., 1994; Jonkman et al., 1996; Rugg et al., 1994).