TRIM27 and myocardial ischemia: For example, TRIM27 is markedly downregulated in murine hearts subjected to myocardial ischemia/reperfusion (I/R) injury and in cardiomyocytes exposed to hypoxia/reoxygenation (H/R); cardiomyocyte‐specific TRIM27 knockout further enlarges infarct size and worsens cardiac dysfunction in I/R mice [16].