To further confirm the mechanism by which the sgRNAs‐guided CRISPR/dCas9 systems activate the expression of BRD7, we established stable cell lines expressing dCas9‐TET1CD‐sgRNA2 and dCas9‐TET1CD‐sgRNA5 by infecting NPC cells with the lentiviral supernatant. The gene discussed is BRD7; the disease is nasopharyngeal carcinoma.