Considering that dCas9‐TET1CD‐sgRNA2&sgRNA5 can suppress the proliferation, migration and invasion of NPC cells by transcriptionally activating BRD7, we aimed to further clarify the impact of BRD7 reactivation on the suppression of the malignant phenotype mediated by this demethylation system. This evidence concerns the gene BRD7 and nasopharyngeal carcinoma.