To confirm the impact of this system, we transiently transfected the LentiCRISPRv2/dCas9‐TET1CD‐sgRNAs (sgRNA1‐5) system into BRD7 low‐expressing NPC cell lines 5‐8F and CNE2, and the results of RT‐qPCR and Western blot assays confirmed that the five sgRNAs‐guided dCas9‐TET1CD system could promote BRD7 expression at mRNA and protein levels in NPC cells to varying degrees when compared to the control group, of which the sgRNA2 and sgRNA5 present the most pronounced effects (Figure 3C,D). This evidence concerns the gene BRD7 and nasopharyngeal carcinoma.