The findings indicated that the expressions of BRD7, P21, Cleaved‐PARP, ZO‐1 and E‐cadherin were significantly up‐regulated in NPC cells with stable expression of dCas9‐TET1CD‐sgRNA2 or dCas9‐TET1CD‐sgRNA5, while the expressions of CDK4, Total‐PARP, Vimentin, N‐cadherin and Snail were down‐regulated, and the co‐expression group exhibited an additive effect of inhibition or enhancement (Figure 6C). Here, CDK4 is linked to nasopharyngeal carcinoma.