Abbreviations: APTT, activated partial thromboplastin time; ASA-PS, the American Society of Anaesthesiologists physical status [22]; BMI, body mass index; COPD, chronic obstructive pulmonary disease; Hb, hemoglobin; IQR, interquartile range; Plt, platelet; PT, prothrombin time; TIVA, total intravenous anaesthesia; VA, volatile anaesthesia. This evidence concerns the gene F2 and chronic obstructive pulmonary disease.